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1

Rivaroxaban pharmacodynamics in healthy volunteers evaluated with thrombin generation and the active protein C system: modeling and assessing inter-individual variability

Siguret, Virginie, Abdoul, Johan, Delavenne, Xavier, Curis, Emmanuel, Carlo, Audrey, Blanchard, Anne, Salem, Joe-Elie, Gaussem, Pascale, Funck-Brentano, Christian, Azizi, Michel, Mismetti, Patrick, Lo

Journal:

Journal of Thrombosis and Haemostasis

Year:

2019

Language:

english

File:

PDF, 640 KB

english, 2019

2

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood

Pailleret, Claire, Jourdi, Georges, Siguret, Virginie, Gouin-Thibault, Isabelle, Gandrille, Sophie, Stepanian, Alain, Curis, Emmanuel, Golmard, Jean-Louis, Gaussem, Pascale, Le Bonniec, Bernard, Samam

Journal:

European Journal of Anaesthesiology

Year:

2018

Language:

english

File:

PDF, 790 KB

english, 2018

3

Evidence that MRP4 is Only Partly Involved in S1P Secretion during Platelet Activation

Decouture, Benoit, Becker, Pierre-Hadrien, Therond, Patrice, Gaussem, Pascale, Bachelot-Loza, Christilla

Journal:

Thrombosis and Haemostasis

Year:

2018

Language:

english

File:

PDF, 91 KB

english, 2018

4

Carmat Bioprosthetic Total Artificial Heart is Associated With An Early Hemostatic Recovery and No Acquired Willebrand Syndrome in Calves

Smadja, David M., Susen, Sophie, Rauch, Antoine, Cholley, Bernard, Latrémouille, Christian, Duveau, Daniel, Zilberstein, Luca, Méléard, Denis, Boughenou, Marie-Fazia, Belle, Eric Van, Gaussem, Pascale

Journal:

Journal of Cardiothoracic and Vascular Anesthesia

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

5

Platelet Functions During Extracorporeal Membrane Oxygenation. PlateletâLeukocyte Aggregates Analyzed by Flow Cytometry as a Promising Tool to Monitor Platelet Activation

Mansour, Alexandre, Roussel, Mikael, Gaussem, Pascale, NÃ©delec-Gac, Fabienne, Pontis, Adeline, FlÃ©cher, Erwan, Bachelot-Loza, Christilla, Gouin-Thibault, Isabelle

Journal:

Journal of Clinical Medicine

Year:

2020

File:

PDF, 1.57 MB

2020

6

Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery

Smadja, David, Godier, Anne, Susen, Sophie, Packard, René, Fabiani, Jean-Noël, Aiach, Martine, Gaussem, Pascale

Journal:

Thrombosis and Haemostasis

Year:

2009

File:

PDF, 71 KB

2009

7

Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential

Guerin, Coralie L., Loyer, Xavier, Vilar, José, Cras, Audrey, Mirault, Tristan, Gaussem, Pascale, Silvestre, Jean-Sébastien, Smadja, David M.

Journal:

Thrombosis and Haemostasis

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

8

280: Circulating endothelial cell levels decrease after vasodilator therapy and are a biomarker of deterioration in pediatric pulmonary hypertension

Lévy, Marilyne, Bonnet, Damien, Mauge, Laetitia, D’Audigier, Clément, Szezepanski, Isabelle, Gaussem, Pascale, Smadja, David

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2013

Language:

english

File:

PDF, 54 KB

english, 2013

9

Usefulness of Initial plasma dabigatran concentration to predict rebound after reversal

Gendron, Nicolas, Gay, Juliette, Lemoine, Marine, Gaussem, Pascale, Lillo-Le Louet, Agnès, Smadja, David M.

Journal:

Year:

2018

Language:

english

File:

PDF, 385 KB

english, 2018

10

Reduced endothelial thioredoxin-interacting protein protects arteries from damage induced by metabolic stress in vivo

Bedarida, Tatiana, Domingues, Alison, Baron, Stephanie, Ferreira, Chrystophe, Vibert, Francoise, Cottart, Charles-Henry, Paul, Jean-Louis, Escriou, Virginie, Bigey, Pascal, Gaussem, Pascale, Leguillie

Journal:

The FASEB Journal

Year:

2018

Language:

english

File:

PDF, 2.51 MB

english, 2018

11

FXa-α2-Macroglobulin Complex Neutralizes Direct Oral Anticoagulants Targeting FXa In Vitro and In Vivo

Jourdi, Georges, Gouin-Thibault, Isabelle, Siguret, Virginie, Gandrille, Sophie, Gaussem, Pascale, Le Bonniec, Bernard

Journal:

Thrombosis and Haemostasis

Year:

2018

Language:

english

File:

PDF, 344 KB

english, 2018

12

Optimizing the Use of Anticoagulants (Heparins and Oral Anticoagulants) in the Elderly

Siguret, Virginie, Gouin-Thibault, Isabelle, Gaussem, Pascale, Pautas, Eric

Journal:

Year:

2013

Language:

english

File:

PDF, 345 KB

english, 2013

13

Human endoglin as a potential new partner involved in platelet–endothelium interactions

Rossi, Elisa, Pericacho, Miguel, Bachelot-Loza, Christilla, Pidard, Dominique, Gaussem, Pascale, Poirault-Chassac, Sonia, Blanco, Francisco J., Langa, Carmen, González-Manchón, Consuelo, Novoa, Jose M

Journal:

Cellular and Molecular Life Sciences

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

14

Delivery management in a woman with thrombocytopenia of the May–Hegglin anomaly type

Habib Chabane, Yves Gallais, Dominique Pathier, Gil Tchernia, Pascale Gaussem

Journal:

European Journal of Obstetrics & Gynecology and Reproductive Biology

Year:

2001

Language:

english

File:

PDF, 47 KB

english, 2001

15

No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease

Smadja, David M., Loriot, Marie-Anne, Hindorff, Lucia A., Mellottee, Lucille, Gaussem, Pascale, Emmerich, Joseph

Journal:

Thrombosis and Haemostasis

Year:

2008

Language:

english

File:

PDF, 489 KB

english, 2008

16

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo

Capra, Valérie, Mauri, Mario, Guzzi, Francesca, Busnelli, Marta, Accomazzo, Maria Rosa, Gaussem, Pascale, Nisar, Shaista P., Mundell, Stuart J., Parenti, Marco, Rovati, G. Enrico

Journal:

Biochemical Pharmacology

Year:

2016

Language:

english

File:

PDF, 2.19 MB

english, 2016

17

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

Smadja, David, Levy, Marilyne, Huang, Lan, Rossi, Elisa, Blandinières, Adeline, Israel-Biet, Dominique, Gaussem, Pascale, Bischoff, Joyce

Journal:

Thrombosis and Haemostasis

Year:

2015

Language:

english

File:

PDF, 713 KB

english, 2015

18

Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension

Bacha, Nour C., Levy, Marilyne, Guerin, Coralie L., Le Bonniec, Bernard, Harroche, Annie, Szezepanski, Isabelle, Renard, Jean M., Gaussem, Pascale, Israel-Biet, Dominique, Boulanger, Chantal M., Smadj

Journal:

Pediatric Pulmonology

Year:

2018

Language:

english

File:

PDF, 600 KB

english, 2018

19

The thrombomodulin-1208/-1209delTT gene promoter polymorphism does not affect basal or LPSdependent monocyte TM mRNA transcription in healthy volunteers

Reny, Jean Luc, Remones, Véronique, Fontana, Pierre, Bieche, Ivan, Desvard, Florence, Aubry, Marie-Laurence, Gaussem, Pascale, Aiach, Martine

Journal:

Thrombosis and Haemostasis

Year:

2005

Language:

english

File:

PDF, 62 KB

english, 2005

20

Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease

David M. Smadja, Pascale Gaussem, Laetitia Mauge, Romaric Lacroix, Sophie Gandrille, Véronique Remones, Séverine Peyrard, Florence Sabatier, Damien Bonnet, Marilyne Lévy

Journal:

Pediatric Cardiology

Year:

2010

Language:

english

File:

PDF, 198 KB

english, 2010

21

0260 : Endoglin in adhesion between endothelial and mural cells

Rossi, Elisa, Smadja, David, Boscolo, Elisa, Langa, Carmen, Arevalo, Miguel A., Pericacho, Miguel, Kauskot, Alexandre, Botella, Luisa M., Gaussem, Pascale, Bischoff, Joyce, Lopez-Novoa, Josè-Miguel, B

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2015

Language:

english

File:

PDF, 220 KB

english, 2015

22

Inefficacy of Platelet Transfusion to Reverse Ticagrelor

Godier, Anne, Taylor, Guillaume, Gaussem, Pascale

Journal:

New England Journal of Medicine

Year:

2015

Language:

english

File:

PDF, 1.24 MB

english, 2015

23

Interleukin-8 Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-forming Cells

BlandiniÃ¨res, Adeline, Hong, Xuechong, Philippe, AurÃ©lien, BiÃ¨che, Ivan, Vacher, Sophie, Rossi, Elisa, Detriche, GrÃ©goire, Gendron, Nicolas, Gaussem, Pascale, Guerin, Coralie L., Melero-Martin, Ju

Journal:

Stem Cell Reviews and Reports

Year:

2020

File:

PDF, 3.74 MB

2020

24

Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus

Alejandro Ruiz-Arguelles, Eduardo Angles-Cano, Beatriz Perez-Romano, Guillermo J. Ruiz-Arguelles, Margarita Deleze, Donato Alarcon-Segovia, Pascale Gaussem

Journal:

American Journal of Hematology

Year:

1995

Language:

english

File:

PDF, 586 KB

english, 1995

25

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis

Bacha, Nour C., Blandinieres, Adeline, Rossi, Elisa, Gendron, Nicolas, Nevo, Nathalie, Lecourt, Séverine, Guerin, Coralie L., Renard, Jean Marie, Gaussem, Pascale, Angles-Cano, Eduardo, Boulanger, Cha

Journal:

Stem Cell Reviews and Reports

Year:

2017

Language:

english

File:

PDF, 3.89 MB

english, 2017

26

Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats

Georges, Jourdi, Sebastien, Lefèbvre, Bernard, Le Bonniec, Emmanuel, Curis, Pascale, Gaussem, Virginie, Lattard, Virginie, Siguret

Journal:

Pesticide Biochemistry and Physiology

Year:

2018

Language:

english

File:

PDF, 582 KB

english, 2018

27

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 â¢ New Orleans - ()] C57. PULMONARY HYPERTENSION: BIOMARKERS, GENETICS, AND GENOMICS: INSIGHTS INTO PATHOGENESIS - Distinctive Patterns Of Circulating Endothelial Cells In Pulmonary Arterial Hypertension And Chronic Thromboembolic Pulmonary Hypertension

Smadja, david M., Mauge, Laetitia, Sanchez, Olivier, Henno, Priscilla, gaussem, pascale, Israel-Biet, Dominique

Year:

2010

File:

PDF, 17 KB

2010

28

Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation

David M. Smadja, Alessandra Bura, Jean Szymezak, Anne Blanchard, Véronique Remones, Michel Azizi, Pascale Gaussem

Journal:

Journal of Cardiology

Year:

2012

Language:

english

File:

PDF, 359 KB

english, 2012

29

0304 : Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

Smadja, David, Levy, Marilyne, Huang, Lan, Rossi, Elisa, Israel-Biet, Dominique, Gaussem, Pascale, Bischoff, Joyce

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2015

Language:

english

File:

PDF, 48 KB

english, 2015

30

Characterization of Cleaved Plasma Protein S with a Monoclonal Antibody-based Assay

Morbœuf, Olivier, Borgel, Delphine, Gaussem, Pascale, Vincenot, Anne, Pittet, Jean-Louis, Aiach, Martine, Gandrille, Sophie

Journal:

Thrombosis and Haemostasis

Year:

2000

Language:

english

File:

PDF, 185 KB

english, 2000

31

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study)

Canonico, Marianne, Brailly-Tabard, Sylvie, Gaussem, Pascale, Setiao, Julie, Rouaud, Olivier, Ryan, Joanne, Carcaillon, Laure, Guiochon-Mantel, Anne, Scarabin, Pierre-Yves

Journal:

Clinical Endocrinology

Year:

2012

Language:

english

File:

PDF, 153 KB

english, 2012

32

Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells

Moussa, Mouhamed Djahoum, Santonocito, Cristina, Fagnoul, David, Donadello, Katia, Pradier, Olivier, Gaussem, Pascale, De Backer, Daniel, Vincent, Jean-Louis

Journal:

Intensive Care Medicine

Year:

2015

Language:

english

File:

PDF, 262 KB

english, 2015

33

The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation

Martin, Anne-Céline, Berndt, Célia, Calmette, Leyla, Philip, Ivan, Decouture, Benoit, Gaussem, Pascale, Gouin-Thibault, Isabelle, Samama, Charles-Marc, Bachelot-Loza, Christilla, Godier, Anne

Journal:

European Journal of Anaesthesiology

Year:

2016

Language:

english

File:

PDF, 296 KB

english, 2016

34

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism

Robert Y.L. Zee, Sherri E. Michaud, Kirsti A. Diehl, Daniel I. Chasman, Joseph Emmerich, Pascale Gaussem, Martine Aiach, Paul M. Ridker

Journal:

Atherosclerosis

Year:

2008

Language:

english

File:

PDF, 101 KB

english, 2008

35

Ticagrelor reversal: in vitro assessment of four haemostatic agents

Calmette, Leyla, Martin, Anne-Céline, Le Bonniec, Bernard, Zlotnik, Diane, Gouin-Thibault, Isabelle, Bachelot-Loza, Christilla, Gaussem, Pascale, Godier, Anne

Journal:

Journal of Clinical Pathology

Year:

2017

Language:

english

File:

PDF, 544 KB

english, 2017

36

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

Goudot, Guillaume, Mirault, Tristan, Arnal, Bastien, Boisson-Vidal, Catherine, Le Bonniec, Bernard, Gaussem, Pascale, Galloula, Alexandre, Tanter, Mickael, Messas, Emmanuel, Pernot, Mathieu

Journal:

Physics in Medicine and Biology

Year:

2017

Language:

english

File:

PDF, 5.63 MB

english, 2017

37

High on-clopidogrel platelet reactivity: Genotyping Can help to optimize antiplatelet treatment

Jean Szymezak, Caroline Moreau, Marie-Anne Loriot, Eric Durand, Hubert Van Viet, Michel Desnos, Pascale Gaussem

Journal:

Thrombosis Research

Year:

2011

Language:

english

File:

PDF, 417 KB

english, 2011

38

Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia

Smadja, David M., Duong-van-Huyen, Jean-Paul, Dal Cortivo, Liliane, Blanchard, Anne, Bruneval, Patrick, Emmerich, Joseph, Gaussem, Pascale

Journal:

Year:

2012

Language:

english

File:

PDF, 720 KB

english, 2012

39

In Vitro Plasma-Induced Endothelial Oxidative Stress and Circulating Markers of Endothelial Dysfunction in Preeclampsia: An Observational Study

Pottecher, Julien, Huet, Olivier, Degos, Vincent, Bonnet, Marie-Pierre, Gaussem, Pascale, Duranteau, Jacques, Ozier, Yves, Mignon, Alexandre, Tsatsaris, Vassilis

Journal:

Hypertension in Pregnancy

Year:

2009

Language:

english

File:

PDF, 193 KB

english, 2009

40

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism

d’Audigier, Clément, Cochain, Clément, Rossi, Elisa, Guérin, Coralie L., Bièche, Ivan, Blandinières, Adeline, Marsac, Bérengère, Silvestre, Jean-Sébastien, Gaussem, Pascale, Smadja, David M.

Journal:

Year:

2015

Language:

english

File:

PDF, 5.64 MB

english, 2015

41

La cytokine fibrogénique TGF-β1 augmente les propriétés angiogéniques des progéniteurs endothéliaux circulants

Evrard, Solène, D’Audigier, Clément, Mauge, Laetitia, Israel-Biet, Dominique, Guerin, Coralie, Bieche, Ivan, Kovacic, Jason, Fischer, Anne-Marie, Gaussem, Pascale, Smadja, David

Journal:

Year:

2015

Language:

french

File:

PDF, 57 KB

french, 2015

42

Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the γ-carboxyglutamic acid-rich domain

BORGEL, Delphine, GAUSSEM, Pascale, GARBAY, Christiane, BACHELOT-LOZA, Christilla, KAABACHE, Tahar, LIU, Wang-Qing, BROHARD-BOHN, Brigitte, LE BONNIEC, Bernard, AIACH, Martine, GANDRILLE, Sophie

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 172 KB

english, 2001

43

Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway

Smadja, David, Dorfmüller, Peter, Guerin, Coralie, Bieche, Ivan, Badoual, Cécile, Boscolo, Elisa, Kambouchner, Marianne, Cazes, Aurélie, Mercier, Olaf, Humbert, Marc, Gaussem, Pascale, Bischoff, Joyce

Journal:

Thrombosis and Haemostasis

Year:

2014

Language:

english

File:

PDF, 573 KB

english, 2014

44

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

Jourdi, Georges, Siguret, Virginie, Martin, Anne Céline, Golmard, Jean-Louis, Godier, Anne, Samama, Charles-Marc, Gaussem, Pascale, Gouin-Thibault, Isabelle, Bonniec, Bernard Le

Journal:

Thrombosis and Haemostasis

Year:

2015

Language:

english

File:

PDF, 729 KB

english, 2015

45

Exploration plaquettaire chez l’Homme

Gaussem, Pascale

Journal:

Year:

2006

File:

PDF, 518 KB

2006

46

Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol

Gaussem, Pascale, Alhenc-Gelas, Martine, Thomas, Jean-Louis, Bachelot-Loza, Christilla, Remones, Veronique, Dali Ali, Fouad, Aiach, Martine, Scarabin, Pierre-Yves

Journal:

Thrombosis and Haemostasis

Year:

2011

Language:

english

File:

PDF, 137 KB

english, 2011

47

Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers

Fontana, Pierre, Gandrille, Sophie, Remones, Véronique, Dupont, Annabelle, Reny, Jean-Luc, Aiach, Martine, Gaussem, Pascale

Journal:

Thrombosis and Haemostasis

Year:

2006

Language:

english

File:

PDF, 256 KB

english, 2006

48

Comparative In Vitro Study of Various Î±2-Adrenoreceptor Agonist Drugs for Ticagrelor Reversal

Porta Bonete, Guillaume, Godier, Anne, Gaussem, Pascale, Belleville-Rolland, Tiphaine, Leuci, Alexandre, Poirault-Chassac, Sonia, Bachelot-Loza, Christilla, Martin, Anne-CÃ©line

Journal:

Journal of Clinical Medicine

Year:

2020

Language:

english

File:

PDF, 1.42 MB

english, 2020

49

Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin α6

David M. Smadja, Ivan Bièche, Dominique Helley, Ingrid Laurendeau, Ghislaine Simonin, Laurent Muller, Martine Aiach, Pascale Gaussem

Journal:

Journal of Cellular and Molecular Medicine

Year:

2007

Language:

english

File:

PDF, 343 KB

english, 2007

50

A monoclonal antibody recognizing the activation domain of protein C in its calcium-free conformation

Anne Vincenot, Jean-Louis Pittet, Martine Aiach, Pascale Gaussem

Journal:

Year:

1998

Language:

english

File:

PDF, 147 KB

english, 1998

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